Basic Info.
Product Description
High Purity Isosorbide Dinitrate Powder Isosorbide Dinitrate 99% CAS 87-33-2
Product Name:Isosorbide dinitrate
Synonyms:1,4:3,6-dianhydro-,dinitrate,d-glucito;1,4:3,6-dianhydro-d-glucitodinitrate;1,4:3,6-dianhydrosorbitol2,5-dinitrate;cardis;carvanil;carvasin;[(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate;Isosorbitol dinitrate
CAS:87-33-2
MF:C6H8N2O8
MW:236.14
EINECS:201-740-9
Purity:99%
Shelf life:2 years
Storage:Keep in cool dry place.
Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure.
Function
Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxid e (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Application
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver. The average bioavailability of isosorbide dinitrate is about 25%.
Comany Information
HOTA wants to help its clients to feel that they have control over their own health. That is why, as a passionate company, we have supplied professional food supplements and plant extracts.
As yet, many people remain unaware that so much can be achieved through food, exercise and supplementation. And that is a missed opportunity, both for the individual and for society. That is why we ensure that our expert knowledge is widely accessible. We actively look for increased knowledge and we substantiate everything that we say, do and produce with scientific research.
We see a future with a better quality of life for everyone: Living Quality. Everything that we strive for has just one single goal: to give you better control of health.
HOTA is dedicated to ensuring every one of our customers enjoys the best in service and product quality. If you have any questions or concerns, our team is always available to help you out!
More Advantages:
1. Leading factory price
2. Huge range of product in stock
3. Research & Development
Our R&D team is continuously developing new product to meet the market.
4. Quality control
At HOTA Co., Ltd, this process is probably the most stringent of all. To us, quality is a commitment. It is a constant process and a continuous improvement.
5. OEM Service: Capsules or Tablets available
Safe, Secure Packaging - Full sealed
1-25kgs: Aluminium bag outside and double plastic bags inside
More than 25kgs: Fiber drum outside and plastic bags inside
Fast, Secure Shipping
| By Express | By air | By sea |
| Suitable for under 25kg | Suitable for more than 25kg | Suitable for more than 500kg |
Q1: When will my order be shipped?
A: Within 3 working days after the payment.
Q2: Can i get some samples?
A: Yes, contact me to know more about sample
Q3: How to confirm the Product Quality before placing orders?
A: Every product is with professional COA. Please be sure about the quality.
If any doubt, sample is available to you to be tested before large quantity order.
Q4: How to start orders or make payments?
A: Payment by T/T, Western Union,MoneyGram etc .
